The Flaming Lips are not a band that you would necessarily associate with the word "accessible" or "popular", and yet their 2002 single, which singer/songwriter Wayne Coyne considers to be the best the band has ever written, is exactly that.
The song, with lyrics by Coyne, was written in response to fellow bandmember Steven Drozd trying to kick his heroin addiction. It concerns the fragility of life - and the beauty within it despite and because of that. The song is absolutely beautiful.
The song is one that they preform live often, and is a crowd pleaser. The band clearly appreciates how much the crowd is pleased.